What part of the brain controls gross motor skills

The central nervous system (CNS) consists of the brain and spinal cord. The brain is an important organ that controls thought, memory, emotion, touch, motor skills, vision, respirations, temperature, hunger, and every process that regulates our body.

The brain can be divided into the cerebrum, brainstem, and cerebellum:

• Cerebrum. The cerebrum (supratentorial or front of brain) is composed of the right and left hemispheres. Functions of the cerebrum include: initiation of movement, coordination of movement, temperature, touch, vision, hearing, speech and language, judgment, reasoning, problem solving, emotions, and learning.

• Brainstem. The brainstem (midline or middle of brain) includes the midbrain, the pons, and the medulla. Functions of this area include: movement of the eyes and mouth, relaying sensory messages (such as, hot, pain, or loud), hunger, respirations, consciousness, cardiac function, body temperature, involuntary muscle movements, sneezing, coughing, vomiting, and swallowing.

• Cerebellum. The cerebellum (infratentorial or back of brain) is located at the back of the head. Its function is to coordinate voluntary muscle movements and to maintain posture, balance, and equilibrium.

More specifically, other parts of the brain include the following:

• Pons. A deep part of the brain, located in the brainstem, the pons contains many of the control areas for eye and face movements.

• Medulla. The lowest part of the brainstem, the medulla is the most vital part of the entire brain and contains important control centers for the heart and lungs.

• Spinal cord. A large bundle of nerve fibers located in the back that extends from the base of the brain to the lower back, the spinal cord carries messages to and from the brain and the rest of the body.

• Frontal lobe. The largest section of the brain located in the front of the head, the frontal lobe is involved in judgment, decision-making, some language functions, personality characteristics, and movement.

• Parietal lobe. The middle part of the brain, the parietal lobe helps a person to identify objects and understand spatial relationships (where one's body is compared to objects around the person). The parietal lobe is also involved in interpreting pain and touch in the body.

• Occipital lobe. The occipital lobe is the back part of the brain that is involved with vision.

• Temporal lobe. The sides of the brain, these temporal lobes are involved in memory, speech, and sense of smell.

The Motor Cortex

The motor cortex, as its name suggests, is the part of the brain most commonly associated with movement. The motor cortex is located predominantly in the anterior part of the frontal lobe and also in some of the parietal lobe. It consists of several distinct parts, namely: the primary motor cortex, the premotor cortex, the supplementary motor area, the primary somatosensory cortex and the posterior parietal cortex.[1]

Of these, the primary motor cortex is arguably the most important, since this region is responsible for initiating voluntary motion. The primary motor cortex is divided into sections, each of which corresponds to a different part of the body (forming a “homunculus”). It controls these body parts by sending signals down cranial nerves to the spinal cord, where they then synapse onto motor neurons. The primary cortex is distinguished histologically by its containing many large pyramidal neurons known as Betz cells.

Research has shown that when an ischemic lesion is administered to the part of the primary motor cortex in mice responsible for controlling their forelimbs, they show a distinct forelimb-dragging behavior in the cylinder test, indicating an inability to control the affected limb.[2] The cylinder test is a simple protocol in which the mouse is placed inside a plastic cylinder and exhibits a natural behavior of attempting to escape by rearing up against the wall. Researchers can then observe the experimental mice and easily see if their ability to rear is deficient compared to controls.

Just in front of the primary motor cortex is a brain region containing a much lower concentration of Betz cells. This has been termed the premotor cortex. This cortex is assumed to play a part in motor control, since its projections to the spinal cord are similar to those of the primary motor cortex. Nonetheless, no-one has so far been able to determine precisely what function the premotor cortex performs in the process of voluntary movement.

Some studies suggest that the premotor cortex assists with more complicated movements, especially those requiring a lot of sensory calibration.[3] While a view seems to have emerged amongst some that the premotor cortex merely plans movements, whereas the primary motor cortex is responsible for actually carrying them out,[4] studies have long shown that both regions are capable of initiating movement and neither is truly subordinate to the other.[5]

The supplementary motor area (SMA) poses even more of a mystery. It is a small region located in front of the part of the primary motor cortex responsible for controlling the legs. In non-human primates, this region contains a body-map, but it does not appear to do so in humans. Specialized functions proposed for the SMA include various kinds of coordination such as coordinating movement on the two sides of the body[6] and organizing actions across time.[7] Other functions proposed include initiating particular kinds of movements as well as controlling posture.[8] It may be that the SMA is a remnant from human ancestors who needed to be capable of dexterously climbing trees.

The somatosensory cortex sits behind the primary motor cortex, and is the main part of the brain concerned with the reception and localization of tactile signals. Like the primary motor cortex, the somatosensory cortex contains a body map, but this map localizes feelings of touch to different parts of the body. This part of the cortex also deals with proprioception, the internal feeling of the limbs that allows them to be oriented without constantly looking at them. Hence, the somatosensory cortex assists in providing feedback and calibrating movements.

The final area of the motor cortex to consider, the posterior parietal cortex, seems specifically tied to hand-eye coordination. Patients with lesions in the posterior parietal cortex find it difficult to focus on and grasp objects.[9] Human PET studies also suggest that the posterior parietal cortex assists with learning new motor tasks.[10]

Cerebellum

The cerebellum, whose name means “little brain” is a walnut-shaped structure that sits below the cortex at the back of the brain, connected to another subcortical region called the pons. The full importance of the cerebellum is still being uncovered, with recent discoveries highlighting its contributions to cognition, but it is most frequently associated with motor coordination.

Humans with lesions in the cerebellum do not suffer any inability to initiate movements, but their movements are no longer well organized in space and time, becoming sudden, excessive and unregulated. It seems like coordinated movement requires a sort of balance of “push and pull” i.e. the motor cortex provides the push, initiating voluntary movements, and then the cerebellum provides the “pull”, reining in the excesses of the movement and smoothing it into something more controlled.

Whereas in humans the cerebellum is quite small compared to the rest of the brain, in many other species—including mice—it’s relative size is much greater, perhaps reflecting the faster and more complicated locomotion required by these species. In mice, the relationship between cerebellar activity and different aspects of locomotion has been studied; one paper found that whereas some of the cells in the cerebellum were highly tuned to the speed of movement, some were tuned to the direction, and others to the rhythm of stepping. The authors suggest that the mouse cerebellum plays a role in adjusting these parameters during motion.[11]

One study has shown that damage to the cerebellum in mice affects their ability to learn in tasks that require strenuous motor activity. Specifically, mice with lesions to different parts of the cerebellum all showed reduced performance compared to controls in the Morris water maze.[12] The Morris water maze is a test whose outcome depends on both navigational memory and motor capability, which requires mice to learn the location of a raised platform in a pool of water and swim to it as quickly as possible. Mice who take longer to find the platform are considered to have performed worse.

Basal Ganglia

The basal ganglia are a collection of brain regions found together, beneath the cortex and just above the pons. The main parts making up the basal ganglia include the striatum, the substantia nigra, the subthalamic nucleus, the globus pallidus and the ventral pallidum. The striatum receives neural signals from the cortex and thalamus and relays them to the rest of the basal ganglia. The basal ganglia then feed information back to the thalamus, mostly via the substantia nigra. Regions in the basal ganglia, most notably the substantia nigra, have been associated with motor control and with disorders of motor coordination.[13]

Lesions of the basal ganglia in humans are correlated with a range of motor deficits, predominantly slowing or lack of movement, but also with loss of control over movement intention.[14] It seems that the main role of the basal ganglia in movement is in suppressing the thalamus and cortex, since overactivity in the basal ganglia is associated with cessation of movement. It is widely accepted that the basal ganglia do not play a role in initiating movements, since lesion patients’ ability to do this is not hindered.

Perhaps the most famous motor disorder associated with the basal ganglia is Parkinson’s Disease (PD). PD patients have jerky, shaky, uncoordinated movements and show a characteristic stooped posture with a shuffling gait. This is thought to be caused by the massive loss of dopaminergic neurons in the substantia nigra, leading to a lack of inhibition of thalamic and cortical circuits, and so, unregulated movements. Treating PD patients with the drug L-dopa restores dopamine concentration in the brain and dampens the shaking.

A number of mouse models have been created to facilitate the study of PD, including the strains Thy1-aSyn and Pitx3. The PD-like symptoms of these model mice can easily be seen by their reduced performance in the rotarod and raised beam tests for motor coordination.[15] In the rotarod test, mice are required to run across a rotating cylinder and maintain their balance. The time that it takes each mouse to fall off, or the maximum speed that each mouse can handle before falling off, is measured and the different mice are compared. In the raised beam test, mice are required to walk across a narrow beam, with the time taken recorded as well as how many times they slip or fall.

What side of the brain controls motor skills?

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